As expected the majority of clinical data, guidelines and opinions on the use of urea and ure-Na for hyponatremia are in the adult population. That data can be found in the Physicians page of this site.
Until recently there was no published dosing or guidance on the use of urea for hyponatremia due to SIADH in pediatrics.
The May 2021 AAP Pediatrics journal published aState of The Art Review titled:
Click either image to link to publication.
Oral urea for the treatment of Chronic syndrome of inappropriate antidiuresis in children. J Pediatri. 2006: Huang EA et al.
Urea as a safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1. J of Ped Endo and Met. Nov 24, 2022. Joy Cui et al.
A Pediatric Case of AVPR2-related Nephrogenic Syndrome of Innappropriate Antidiuresis. Child Kidney Disease 2020. Hyunwoo Bae MD et al.
Please refer to the Physicians section for more information on patients not appropriate for ure-Na.
Please see the Physicans section for more information on BUN and Serum Creatinine.
Ure-Na is available in most American hospitals. If ure-Na is not available for inpatient use at the institutions where you round, please request Inpatient Pharmacy to conduct a review for addition to inpatient formulary.
Please direct Pharmacy to the Pharmacist section of ure-na.com for any pre-review questions or information they may need.
Ure-Na is often covered by Health Insurance under a patient's Medical Benefit (not pharmaceutical benefit) as enteral nutrition, enteral therapy or as a medically necessary food. Plans that cover are Managed Medicare (Medicare HMO, PPO and Advantage), Commercial and some Medicaid
While most of our patients are on ure-Na, for patients where affordability is an issue, we have a lower priced product that is stabilized and bulk packed, but is not flavor masked.
More information can be found at UreaPro.com
Please see the Insurance section of this site for more information on insurance reimbursement options.
Ingredients in descending order: synthetically derived urea powder, natural flavors, maltodextrin, citric acid, calcium silicate, sucralose.
For some, especially people with diabetes the caloric content of ure-Na is important. Each sachet of ure-Na contains less than 15 calories. The calories are derived from the maltodextrin.
